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“Now, post-surgery and post recovery, I am able to see in dimmer lighting with my left eye,” Cook said. A treatment that used CRISPR was found to be safe and efficacious in improving vision among a small sample of patients with inherited blindness in the Phase 1/2 clinical trial that Cook participated in. Months following the treatment, Cook was sitting with friends on a balcony that had Christmas lights wrapped around the railing. Courtesy Olivia CookBefore the treatment, Cook said that she sometimes could conceal the vision challenges she has had. Mass Eye and EarKalberer described the CRISPR treatment as “groundbreaking,” but warned it’s not a cure.
Persons: Olivia Cook, Cook, , ” Cook, , I’ve, “ I’d, you’d, CRISPR, Eric Pierce, Brigham, “ We’re, ” Pierce, Jason Comander, , Michael Kalberer, Kalberer, it’s, “ It’s, It’s, Pierce, Editas, We’re, Art Caplan, ” Caplan, , Vlad Diaconita, ” Diaconita, Dr, Sanjay Gupta, Aliaa Abdelhakim Organizations: CNN, Missouri State University, New England, of Medicine, Mass, Harvard Medical School, Editas Medicine, Perelman School of Medicine, University of Pennsylvania, University of Michigan, University of Miami, Oregon Health & Science University, US Food and Drug Administration, CEP290, pharma, NYU Grossman School, Medicine’s Department of Population Health, Columbia University Vagelos College of Physicians and Surgeons, CNN Health Locations: Springfield, United States, CEP290
Fifty years into the history of hip-hop, street to stage transfers remain tricky. Hip-hop dance is diverse and globally dominant, but when it’s put on concert stages, something often gets lost. Over the past two weekends, the city’s newest theater, the marble cube of the Perelman Performing Arts Center, hosted “Motion/Matter,” a festival of street dance. The four dancers of Supa Rich Kids — from Ivory Coast, Nigeria and Spain, led by Oulouy — began caked in white powder, two inert on the ground, the third dragging the limp body of the fourth. Then they changed into wild outfits, screamed “African party!” and pulled members of the audience into the dance.
Persons: it’s, , , Supa, Oulouy —, James Brown Organizations: Perelman Performing Arts Center, “ Afrikan Party Locations: Africa, Europe, Asia, Ivory Coast, Nigeria, Spain
CNN —About this time last year, Ben Shelton was an up-and-coming tennis player taking his first-ever trip outside the United States. It figures, then, that Shelton enters his second full season as a professional tennis player with weighty expectations. “There’s not one path for everybody, and I don’t think that my path is perfect, but it really worked for me,” says Shelton. I don’t feel like I have too many miles on my body yet.”On the court, Shelton is physical and powerful. I think I’m also more comfortable taking away time and coming forward to the net.
Persons: Ben Shelton, Shelton, ” Shelton, Skip, Novak Djokovic, Brad Gilbert, Andy Roddick, Frances Tiafoe, Geoff Burke, Reuters It’s, Roddick, Taylor Fritz, Tommy Paul, coy, someone’s, , Aslan Karatsev, Kazuhiro Nogi, – Carlos Alcaraz, Coco Gauff, Emma Raducanu, – Shelton, “ There’s, , haven’t, Scott Perelman, Bryan, Djokovic, Mike Stobe, Shelton – Organizations: CNN, CNN Sport, Melbourne, ATP, Reuters, Football, Japan, University of Florida, NCAA, Roddick, Georgia Tech Locations: United States, Australia, Japan, American, USA, AFP, Georgia, Florida, Tokyo, Swiss, tennis
The Times/KFF Health News data analysis was based on the Health and Retirement Study, a nationally representative longitudinal survey of about 20,000 people over age 50. The analysis defined people ages 65 and above as likely to need long-term care if they were assessed to have dementia, or if they reported having difficulty with two or more out of six activities of daily living. The analysis’ definition of needing long-term care assistance is conservative and is in line with criteria most long-term care insurers use in determining whether they will pay for services. The analysis was developed in consultation with Norma Coe, an associate professor of medical ethics and health policy at the Perelman School of Medicine at the University of Pennsylvania. The financial toll on middle-class and upper-income people needing long-term care was examined by reviewing data that the H.R.S.
Persons: Norma Coe Organizations: KFF Health, Health, Perelman School of Medicine, University of Pennsylvania
CNN —Establishing healthy bedtime habits for your child early on is vital if at least one parent has chronic sleep difficulties, suggests new research on genetics and children’s sleep disorders. It does, say experts behind the first study providing evidence that genetic susceptibility to being a “poor sleeper” can also be found early in life. Children genetically predisposed to insomnia had more insomnia-related sleep issues such as difficulty falling asleep or frequently waking up during the night, according to the study published Wednesday in the Journal of Child Psychology and Psychiatry. “You would think that, sure, if it’s genetically determined, why wouldn’t it manifest earlier in life?”Good sleep hygiene for kidsThere is still hope for your child’s sleep health. “If your child is a natural late sleeper, then don’t force them to go to sleep early,” Sehgal added.
Persons: Catherine Falls, , Eus van Someren, , they’re, Amita Sehgal, wasn’t, Sehgal, , Desana, ” Kocevska, they’ve, ” Sehgal Organizations: CNN, Child Psychology, Psychiatry, Getty, Netherlands Institute for Neuroscience, Sleep Institute, University of Pennsylvania Perelman School of Medicine, Erasmus Medical Center Locations: Catherine, Amsterdam, Rotterdam, Netherlands
Some of them are imprinted with the text of the Second Amendment, others a rallying cry: “We fight fascists.” Among the most eye-catching is an ad for N.R.A. memberships, with its promise of “$5,000 Accidental Death and Dismemberment insurance.”But what about intentional deaths? “Watch Night,” a new multigenre hybrid show, is interested in those, specifically the ones fueled by homegrown prejudice. He wrote the libretto for “We Shall Not Be Moved” (2017), an opera inspired by the police bombing in 1985 of a Philadelphia house occupied by Black activists, with an artistic team that included Jones and Lauren Whitehead, the “Watch Night” dramaturg. Unfortunately, those experiences have not helped focus this new production.
Persons: Perelman, Bill T, Jones, Marc Bamuthi Joseph, Tamar, kali, Joseph, Carlos Simon, , George Floyd, Lauren Whitehead Organizations: Perelman Performing, Emanuel African Methodist Episcopal Church, Minnesota Orchestra, Black Locations: Charleston, S.C, Pittsburgh, “ brea, Philadelphia
Deb Perelman, the best-selling cookbook author and creator of Smitten Kitchen, tends to focus her social media posts on her work, like pasta or chocolate chip cookie recipes. Of course, many people see immense importance in posting on social media about the war. Social media feeds have focused on major news events many times before. The Israeli-Palestinian conflict is a uniquely thorny and divisive issue to navigate on social media, though, particularly for those not educated about the region or its history, or who are still forming their opinions. People of both faiths have asked her to post about the war on social media, she said, and sending her graphic images.
Persons: Deb Perelman, , , Perelman, ” Ms, , outpourings, Israel, Phoebe Lind, Maddie Coppola, Israel ”, Coppola, Ms, Andrey Romanov, Nazhath Faheema, Faheema, — they’re, Minaa, ’ ”, Agneez Kang, Kang, ” Yiwen Lu Organizations: Harvard, Artforum, Harper’s, Facebook, LinkedIn Locations: Israel, Gaza, Washington, New York, Singapore,
Doubts abound about a new Alzheimer’s blood test
  + stars: | 2023-10-18 | by ( Judith Graham | ) edition.cnn.com   time to read: +10 min
The Quest Diagnostics blood test, AD-Detect, measures elevated levels of amyloid-beta proteins, a signature characteristic of Alzheimer’s. But Alzheimer’s researchers and clinicians aren’t convinced the Quest test is backed by sound scientific research. Though blood tests for Alzheimer’s are likely to become common in the years ahead, the Alzheimer’s Association said it’s premature to offer a test of this kind directly to consumers. Because the science behind blood tests for Alzheimer’s is still developing and because “patients may not really understand the uncertainty of test results,” Edelmayer said, the Alzheimer’s Association “does not endorse the use of the AD-Detect test by consumers.”Quest’s blood test is one of several developments altering the landscape of Alzheimer’s care in the United States. The bottom line: Before taking a test, “older adults need to ask themselves, ‘Why do I want to know this?
Persons: aren’t, Alzheimer’s, Michael Racke, , there’s, Suzanne Schindler, St . Louis, That’s, ” Schindler, Racke, Meera Sheffrin, , Rebecca Edelmayer, ” Edelmayer, Eric Widera, Dr, Sanjay Gupta, Emily Largent, ’ ”, Munro Cullum Organizations: Health, Diagnostics, Alzheimer’s Association, Quest, University of Michigan, International Conference, Washington University School of Medicine, Senior, Stanford Healthcare, The University of Michigan, FDA, National Institute, Aging, University of California, Get CNN, CNN Health, University, Pennsylvania’s Perelman, of Medicine, HIPAA, University of Texas Southwestern Medical Center, Kaiser Health, KFF Locations: U.S, San Diego, St ., United States, San Francisco
It can create a feeling of numb office dystopia, as focusing on spreadsheets can make real-world problems feel imagined. A Harvard Medical School analysis says the fight, flight, or freeze instinct can kick in during tough news cycles. AdvertisementAdvertisementHe's describing a sense of numbness some workers feel as more and more return to the office this fall. The fight, flight, or freeze instinct can kick in during tough news cycles or rough personal events, according to a Harvard Medical School analysis . The freeze instinct might appear as indifference on the surface, but it can manifest as generalized anxiety, or even nightmares.
Persons: , Charli D'Amelio, Elon, Walt Disney, Joe Fenti, Fenti, Lily Brown, Brown, Ben Sweeny's, Sweeny Organizations: Harvard Medical, Service, Center, Perelman School of Medicine, University of Pennsylvania Locations: Boston
In an extended portion of Eisai’s main Leqembi trial, CAA was associated with one death. 'THE DIGNITY OF RISK'Hillerstrom said the groups are "very strongly" lobbying Eisai and Lilly to conduct the safety trials in Down syndrome, and said he has been meeting with the companies to push them to design such trials. Lilly declined to comment on whether it is considering either a safety trial or taking part in that study. An Eisai spokeswoman said the company "has no immediate plans" to conduct clinical trials of Leqembi in people with Down syndrome. The company is collaborating with LuMind in a study gathering data on how Alzheimer's manifests in people with Down syndrome.
Persons: Oskar Hillerstrom, Lianor, Hampus, Brian Snyder, Lianor da Cunha, Oskar, de Oeiras, Teresa, Oskar’s, Hampus Hillerstrom, Eli Lilly's, LuMind, Hillerstrom, Lilly, Emily Largent, Beau Ances, Louis, I've, Ances, I'm, Michael Rafii, William Mobley, Mobley, Dawn Brooks, donanemab, Margot Rhondeau, Hannah, Julie Steenhuysen, Caroline Humer, Bill Berkrot Organizations: REUTERS, Rights, Reuters, CAA, University of Pennsylvania Perelman School of Medicine, Medicare, U.S . Food, Drug Administration, Washington University, National Institute, Aging, University of Southern, UC San Diego School of Medicine, LuMind, Syndrome, Thomson Locations: Lexington , Massachusetts, U.S, Santo, Portugal, United States, St, University of Southern California
mRNA vaccine: 5 things to know
  + stars: | 2023-10-02 | by ( Katie Hunt | ) edition.cnn.com   time to read: +5 min
Here are five things to know about Karikó and Weissman’s game-changing research and mRNA vaccines. What mRNA doesMessenger RNA, or mRNA, is a form of nucleic acid that tells cells what to do based on the information contained in DNA. Messenger RNA-based vaccine technology doesn’t rely on a modified version of a virus to produce an immune response. Potential beyond fighting Covid-19The advent of mRNA vaccine technology has led to safe and strong protection against Covid-19. And mRNA technology is also being checked out as a possible alternative to gene therapy for intractable conditions such as sickle cell disease.
Persons: Katalin Karikó, Drew Weissman, Peggy Peterson, Robin Shattock, ” Shattock, , Karikó, Weissman, , Roberts, Thomas Perlmann, it’s Organizations: CNN, University of Pennsylvania, Penn Medicine, Imperial College London, Covid, Penn’s Perelman, of Medicine, Vaccine, Perelman School of Medicine, Nobel Assembly Locations: Hungary
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Persons: Dow Jones, perelman
When the center was being built, Mr. O’Farrill was part of an advisory committee of artists; he urged the center to pay close attention to acoustics. He’s a very thoughtful man, and he’s looking to expand the conversation on what performing arts is, what elitism does to the arts. Maybe you make it by bringing music that’s just so incredible that everybody wants to get on the subway and go down there. For a performing arts center to support that speaks straight to my heart. And we have the place called the Perelman Center right next to ground zero that is open to the whole world.
Persons: Arturo O’Farrill, O’Farrill, , ” Mr, “ That’s, He’s, ” Laurie Anderson, , , it’s, that’s, Ms, Kidjo, I’ve Organizations: , Refuge, Jazz Alliance, clarion, Perelman Center Locations: New York City, Americas, Europe, Paris, Benin, Brooklyn
New York’s civic leaders and arts administrators have spoken for two decades of the importance of building a haven of artistic creation on a site that had become synonymous with tragedy and death. “Here, on this very site, where so much loss and devastation took place,” said Michael R. Bloomberg, the billionaire former mayor who is chairman of the institution’s board, “the arts will bring a special sense of hope for the future.”Various ideas for the space percolated and fizzled for years, until Ronald O. Perelman, the billionaire businessman whom the building is named after, jump-started the project with a $75 million donation. It was Mr. Bloomberg who brought the project to fruition, contributing the largest portion of money: $130 million. Although it is Mr. Perelman’s name on the building, Mr. Bloomberg was at the center of much attention Thursday night, posing with benefactors and celebrities like Michael Douglas and Liev Schreiber on a red carpet at a cocktail hour before the performance, where guests sipped champagne and ate miniature cheeseburgers and pigs in blankets.
Persons: , Michael R, Ronald O, Perelman, Bloomberg, Michael Douglas, Liev Schreiber Organizations: Bloomberg
The new Perelman Performing Arts Center is the most glamorous civic building to land in New York in years. You may have noticed the building under construction if you were near the World Trade Center in Lower Manhattan during the past year or so. A floating, translucent marble cube, it nestles at the foot of One World Trade Center, just eight stories high, a runt in a herd of mega-tall commercial skyscrapers but impossible to miss. Back then, the city was all-consumed by grief and fear, its economy in free-fall, ground zero still a smoldering gravesite. We were reminded just this week of the toll when the names of the thousands of dead were again read aloud.
Persons: Osama bin Laden Organizations: Perelman Performing Arts Center, World Trade Center Locations: New York, Lower Manhattan
How Covid Affects the Heart
  + stars: | 2023-09-07 | by ( Dana G. Smith | More About Dana G. Smith | ) www.nytimes.com   time to read: +2 min
Others may develop because Covid is also associated with the onset of risk factors for heart disease, most notably hypertension. How vaccines reduce the riskResearch has shown that people who are vaccinated are roughly 40 to 60 percent less likely to have a heart attack or stroke following a Covid infection than those who are unvaccinated. This may be because vaccinated people are less likely to develop severe Covid, which in turn lowers the risk of many of these heart-related issues. There is a small risk of developing myocarditis (inflammation of the heart muscle) in the weeks after getting an mRNA Covid vaccine made by Pfizer-BioNTech or Moderna. For males 30 and older, the risk of myocarditis was 28 times higher from Covid than from the vaccine.
Persons: , Helene Glassberg, who’ve, Laffin, myocarditis Organizations: University of Pennsylvania Perelman School of Medicine, Pfizer, Centers for Disease Control, Prevention
Envisioned two decades ago to add vibrancy and draw people to a place of devastation and mourning, the Perelman Performing Arts Center is finally arriving at a very different ground zero. Still, organizers believe the arts space, also called “PAC NYC,” has an important role to play in one of the most sensitive, historic spaces in the United States. “The performing arts center is kind of an amenity for a luxury neighborhood that they built,” said Todd Fine, who runs a advocacy business for historical preservation in lower Manhattan. Early on, the arts center was to house three established groups — two theaters and a visual arts museum — plus a new museum celebrating freedom. Then he came to see it as a step forward for the trade center and on a personal level, an embrace of living life fully.
Persons: It's, , Khady Kamara, , Bill Rauch, Joshua Ramus, Mike Bloomberg, Ronald Perelman, “ There’s, ” Bloomberg, Laurence Fishburne, Jenna Bush Hager, Barbara Pierce Bush, ” Rauch, Kamara, Todd Fine, Rauch, Perelman, Craig Peterson, James Giaccone, Joseph Giaccone, ” Giaccone Organizations: Trade, Perelman Performing Arts Center, “ PAC, Performing Arts Center, Pentagon, Manhattan Cultural Council, Tuesday's Locations: United States, Pennsylvania, Afghanistan, Manhattan
This is a season of transition for two of New York’s most important arts institutions. And Jaap van Zweden, the New York Philharmonic’s music director since 2018, starts his final year in the position with help from Yo-Yo Ma, Steve Reich and Schubert. Grand orchestras like the Chicago Symphony and Staatskapelle Berlin at Carnegie Hall; the Emerson String Quartet’s farewell; and premieres by Kate Soper and Ted Hearne are among the other highlights coming this fall. And Matthew Ozawa’s staging for Detroit Opera aims to be a corrective to stereotypes about Japanese women and culture (Oct. 7-15). DEATH OF CLASSICAL The impresario Andrew Ousley’s bleakly winking concert series, performed in crypts and catacombs, includes the Calidore Quartet, which will present Beethoven’s Op.
Persons: Jake Heggie’s, Malcolm X ”, Florencia, Jaap van Zweden, Ma, Steve Reich, Schubert, Kate Soper, Ted Hearne, Phil Chan, Matthew Ozawa’s, PERELMAN, , Mahani Teave, Andrew Ousley’s bleakly, Lowell Liebermann’s, Maxim Lando, Bach’s “ Goldberg, Hanzhi Wang, David Lang’s Pulitzer, Organizations: Metropolitan Opera, York, Chicago Symphony, Berlin, Carnegie Hall, Emerson Colonial Theater, Detroit Opera, Trinity Church Wall, Easter Locations: el Amazonas, Boston, American
CNN —The weight loss drug Wegovy was shown to reduce the risk of heart attack, stroke or heart disease-related death by 20% in a major clinical trial in people with cardiovascular disease, the first to show a weight loss drug alone can have such protective effects. It called the five-year trial “Select.”The finding of a 20% reduction in heart risk is higher than many experts had anticipated. A similar trial for the type 2 diabetes drug Ozempic, which uses the same ingredient, semaglutide, previously showed it could reduce cardiovascular risk by 26% — but no trial had yet shown a risk reduction in people without diabetes. It said it will present detailed results from the trial at a scientific conference later this year. It’s awaiting US Food and Drug Administration approval for weight loss as well.
Persons: Wegovy, 2.4mg, , Martin Holst Lange, Novo, Dr, Willa Hsueh, Jena Shaw Tronieri, Sanjay Gupta, Fuller, Steven Nissen, Eli Lilly, It’s, ” Nissen, he’d Organizations: CNN, Novo Nordisk, Diabetes, Metabolism Research, Wexner, The Ohio State University, Clinical Services, Center, Perelman School of Medicine, University of Pennsylvania, Nordisk, CNN Health, Cleveland, Food and Drug
For years, experts have debated what to advise older adults in this situation. Only 27% to 44% of older adults meet these guidelines, according to various surveys. Epidemiologic research suggests that the ideal body mass index (BMI) might be higher for older adults than younger adults. The study’s conclusion: “The WHO healthy weight range may not be suitable for older adults.” Instead, being overweight may be beneficial for older adults, while being notably thin can be problematic, contributing to the potential for frailty. Indeed, an optimal BMI for older adults may be in the range of 24 to 29, Carl Lavie, a well-known obesity researcher, suggested in a separate study reviewing the evidence surrounding obesity in older adults.
Persons: they’ve, , Mitchell Lazar, we’re, John Batsis, Anne Newman, , Carl Lavie, Lavie, , ” Lavie, Newman, you’re, Dinesh Edem, Dennis Kerrigan, Katie Dodd Organizations: CNN, US Centers for Disease Control, Institute for Diabetes, University, Pennsylvania’s Perelman, of Medicine, University of North Carolina School of Medicine, Center for Aging, Health, University of Pittsburgh School of Public Health, BMI, World Health Organization, WHO, University of Pittsburgh, University of North, University of Arkansas, Medical Sciences, Henry Ford Health, Kaiser Health, KFF Locations: , Chapel Hill, New Orleans, University of North Carolina, Michigan
This counters a claim spreading online that misinterprets public data to suggest it shows the vaccines did not prevent deaths. The data shows there were 22,361 COVID deaths in England and Wales in 2022 where the individuals were vaccinated three times. This would be 80%, not 92%, of all COVID deaths for 2022, she said. The 92% pertains to COVID deaths of anyone who ever received a vaccine dose, the spokeswoman added. Moreover, the online claim’s wider suggestion of vaccine ineffectiveness is a misrepresentation of COVID deaths data, she said.
Persons: COVID, , Jeffrey Morris, biostatistics, Read Organizations: National Statistics, Reuters, Triple, Twitter, Facebook, England, Perelman School of Medicine, Wharton School, University of Pennsylvania Locations: England, Wales, COVID
Inside the Shed’s Sonic Sphere
  + stars: | 2023-07-02 | by ( Zachary Woolfe | ) www.nytimes.com   time to read: +2 min
The xx remix did nicely separate the bass, coming up palpably but not too heavily out of the bottom of the sphere, from the voices around and above. For all the souped-up spiffiness of the Sonic Sphere, the programming on Saturday felt like a retread of artists who were more interesting when Alex Poots, the Shed’s artistic director, presented them during his stint at the Park Avenue Armory uptown. Levit, the following year, played Bach as part of an ornate concentration exercise orchestrated by Marina Abramovic. Both of them on Saturday were under 40 minutes, but I found myself getting antsy well before time was up. Perhaps the audiences at Burning Man, the techno-hippie hedonist bonanza in the Nevada desert where a Sonic Sphere was built last year, were more engrossed, experiencing it on harder drugs than the Coke Zero I’d had with dinner.
Persons: Mari ”, Rirkrit Tiravanija, Alex Poots, Bach, Marina Abramovic Organizations: Armory, Perelman Performing Arts Center Locations: Levit, Nevada
Year after year, plans to build a cultural institution on the World Trade Center site percolated, only to then fizzle out. The International Freedom Center, the Joyce Theater, the Drawing Center, the Signature Theater, New York City Opera, a design by Frank Gehry — all were discussed as possibilities, but none went anywhere. Now, two decades after the 2003 master plan for ground zero called for a cultural component, a performing arts center is finally preparing to open there in September. The center, which will ultimately cost $500 million — more than twice what was projected in 2016 — is now on track to have a ribbon cutting on Sept. 13. “I can afford it,” Mr. Bloomberg said of his largess during a recent hard hat tour of the center.
Persons: Frank Gehry —, Ronald O, Perelman, Michael R, Barbra Streisand, , , ” Mr, Bloomberg, Organizations: World Trade, Freedom Center, Joyce Theater, New York City Opera, Bloomberg Locations: New York
The good, bad and ugly about BMI
  + stars: | 2023-05-22 | by ( Sandee Lamotte | ) edition.cnn.com   time to read: +8 min
Short for body mass Index, BMI is nothing more than a crude measurement of a person’s body fat based on height and weight. Yet critics say the term BMI has become a societal judgment by lumping individuals into arbitrary categories that perpetuate misconceptions about body weight. “Yet it has become completely medicalized that health equals weight, weight equals health based on BMI. Conversely, BMI can underestimate body fat in older adults and anyone who has lost muscle, according to the Harvard T.H. More conundrums: Women naturally have more body fat and less muscle mass than men, while some racial and ethnic groups are genetically predisposed to carry more or less lean muscle mass and body fat.
CNN's Chloe Melas, shown with her husband, Brian Mazza, and two sons, has been open about her journey with IVF to grow her family. Infertility affects about 1 in 6 people, according to a recent report from the World Health Organization previously covered by CNN. To find out what could be helpful for others, I talked to several people for their advice on what to do and not do when supporting a loved one going through infertility. She regularly covers the topic of infertility and recently published a piece about how to help people going through infertility. “Infertility treatments are often physically taxing.
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